Southampton take on Bournemouth at St Mary's Stadium in the Premier League.
Leicester City welcome Tottenham to the King Power Stadium in the Premier League.
Newcastle United take on Brighton and Hove Albion at St James' Park in the Premier League. A Beram Kayal strike saw the Seagulls secure three points on their visit here last season.
West Ham United take on Manchester United at the London Stadium in the Premier League. The Hammers took all three points in this fixture last season, winning 3-1.
Chelsea take on Liverpool at Stamford Bridge in the Premier League. These sides last met in the UEFA Super Cup in a clash won on penalties by Liverpool.