Manchester City travel to the Santiago Bernabeu to take on Real Madrid in the first leg of their UEFA Champions League Round of 16 match.
Lyon and Juventus meet in the UEFA Champions League at Parc Olympique Lyonnais as they play their Round of 16 first leg tie.
Relegation-battling Norwich City face a tough test as they welcome top four-chasing Leicester City to Carrow Road in Friday Night Football from the Premier League.
Brighton host rivals Crystal Palace at the AMEX Stadium as they meet in the Premier League.
Nigel Pearson's Watford welcome title-chasing Liverpool to Vicarage Road in the Premier League. A Mohamed Salah brace was enough to see the Reds over the lines in the reverse game.
Carlo Ancelotti's Everton take on Manchester United at Goodison Park in the Premier League. The sides shared the spoils in a 1-1 draw in the reverse fixture.